ADAM17: a molecular switch to control inflammation and tissue regeneration
Abstract
A disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor-α converting enzyme (TACE), is a membrane-bound enzyme that cleaves cell surface proteins, such as cytokines (e.g. TNFα), cytokine receptors (e.g. IL-6R and TNF-R), ligands of ErbB (e.g. TGFα and amphiregulin) and adhesion proteins (e.g. L-selectin and ICAM-1). Here we examine how ectodomain shedding of these molecules can alter their biology and impact on...
Paper Details
Title
ADAM17: a molecular switch to control inflammation and tissue regeneration
Published Date
Aug 1, 2011
Journal
Volume
32
Issue
8
Pages
380 - 387
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