Affinity and selectivity of [¹¹C]‐(+)‐PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo

Although [ 11 C]‐(+)‐PHNO has enabled quantification of the dopamine‐D3 receptor (D3R) in the human brain in vivo, its selectivity for the D3R is not sufficiently high to allow us to disregard its binding to the dopamine‐D2 receptor (D2R). We quantified the affinity of [ 11 C]‐(+)‐PHNO for the D2R and D3R in the living primate brain. Two rhesus monkeys were examined on four occasions each, with [ 11 C]‐(+)‐PHNO administered in a bolus + infusion...