Abstract SY16-01: The impact of oxygen availability on angiogenesis: HIF/Notch pathway interactions

The therapeutic manipulation of angiogenesis holds great promise for treating diverse pathological conditions including cancer, macular degeneration, atherosclerosis, and peripheral arterial disease (PAD). However, the ability to reliably inhibit (or promote) angiogenesis in clinical settings requires a thorough appreciation of the complex molecular events that coordinate vessel sprouting and remodeling. It is well established that these...