Discussing the diagnosis of HPV-OSCC: common questions and answers

Published on Sep 1, 2013in Oral Oncology3.979
· DOI :10.1016/J.ORALONCOLOGY.2013.06.002
Carole Fakhry37
Estimated H-index: 37
(Johns Hopkins University),
Gypsyamber D'Souza53
Estimated H-index: 53
(Johns Hopkins University)
summary Human papillomavirus (HPV) is responsible for a rising proportion of oropharyngeal squamous cell cancers (OSCCs). HPV-positive OSCCs (HPV-OSCCs) are associated with oral HPV infection and sexual behavior. Patient questions regarding risk factors, prognosis and implications for past, present and future relationships often arise. This manuscript addresses frequently asked questions by patients with HPVOSCC and their families. A framework for clinicians to address these conversations and the limitations of our present knowledge base is also presented. Human papillomavirus (HPV), a sexually transmitted infection, is now responsible for the overwhelming majority of oropharyngeal squamous cell cancers (OSCCs) in the United States (U.S.). Historically, tobacco and alcohol use accounted for the majority of head and neck cancers. However, with the decline of tobacco use in the U.S., the incidence of smoking-related (HPV-negative) oropharyngeal malignancies has decreased [1]. The proportion of oropharyngeal cancers attributable to HPV (HPV-positive OSCC; HPVOSCC) has risen substantially in the U.S. Indeed, while only 16% of OSCCs in the 1980s were HPV-positive, approximately 73% of tumors in the 2000s were HPV-positive. Not only is the proportion
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