Last. A.W. Barrett(QVH: Queen Victoria Hospital)H-Index: 9
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Abstract null null Objectives null To determine the overall recurrence rate (RR) and malignant transformation rate (MTR) of high grade oral mucosal epithelial dysplasias (HGOED). null null null Materials & Methods null A clinicopathological review of records of patients diagnosed with a unifocal HGOED between 2004 and 2016 on incisional biopsy who then underwent excision. The mean duration of follow-up was 47.7 months (±29.9 SD). null null null Results null Full demographic, historical and histo...
#1Andrey Finegersh(UCSD: University of California, San Diego)H-Index: 11
#2Rohith S. Voora(UCSD: University of California, San Diego)
Last. Ryan K. Orosco(UCSD: University of California, San Diego)H-Index: 18
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Abstract null null Background null Hypopharyngeal cancer is associated with poor survival. Robotic surgery is emerging as a treatment for hypopharyngeal tumors, but no rigorous data are available to assess its effect on survival. null null null Methods null The National Cancer Database (NCDB) was used to identify patients with T1 and T2 hypopharyngeal tumors undergoing robotic surgery, laser surgery, and primary radiation with or without chemotherapy from 2010 to 2016. All adult patients with av...
Last. Hongxia Ma(Nanjing Medical University)H-Index: 51
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OBJECTIVE CircRNAs are critical gene modulators in tumor initiation and progression. However, the expression pattern and molecular pathogenesis of circRNAs in oral squamous cell carcinoma (OSCC) are still poorly characterized. METHODS RNA sequencing with CIRCexplorer2 pipeline was performed to identify circRNAs in 46 tumor-normal paired tissues from OSCC patients. Another set of 48 head and neck squamous cell carcinoma samples from the MiOncoCirc database were utilized as an independent validati...
Last. Manuele Casale(Università Campus Bio-Medico)H-Index: 18
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Abstract null null Objectives null To define the accuracy of autofluorescence-based (AF) and chemiluminescence-based (CL) systems in the diagnosis of oral dysplastic and malignant lesions in addition to the Conventional Oral Examination (COE). null null null Materials and Methods null The study was performed according to the PRISMA-DTA guidelines. null null null Results null A total of 2631 oral cavity lesions (AF, n = 2076; CL, n = 555) from 26 studies (AF = 17; CL = 9) was used for calculation...
Last. Zhi-Jun Sun(WHU: Wuhan University)H-Index: 50
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Abstract null null Objectives null Anti-PD-1/PD-L1 therapy has recently been approved for head and neck squamous cell carcinoma (HNSCC). However, given that large numbers of patients with HNSCC do not respond to PD-1/PD-L1 antibodies, combination strategies for elevating the response rate need to be further investigated. The goal of this study was to explore the possibility of dual-targeting CD155/TIGIT and PD-1/PD-L1 signalling in HNSCC. null null null Materials and methods null Multiplex flow ...
#2Sushan Gupta(HBNI: Homi Bhabha National Institute)H-Index: 1
Last. Jigeeshu V Divatia(HBNI: Homi Bhabha National Institute)H-Index: 22
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OBJECTIVES Tracheostomy (TT) and delayed extubation (DE) are two approaches to postoperative airway management in patients after major oral cancer surgery. We planned a study to determine the safety of overnight intubation followed by extubation the next morning (DE) compared to elective TT and to identify factors that were associated with a safe DE (maintenance of a patent airway). MATERIAL AND METHODS We conducted a prospective observational study in a tertiary referral cancer care center. We ...
Last. Ata S. Moshiri(UW: University of Washington)H-Index: 6
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OBJECTIVES While the incidence of cutaneous melanoma has dramatically increased in recent years, oral malignant melanoma (OMM) remains a rare form of noncutaneous melanoma with poor survival. PRAME (PReferentially expressed Antigen in MElanoma) is reported to have diagnostic and some prognostic utility in cutaneous melanomas and some head and neck malignancies. We sought to explore the diagnostic utility of PRAME in OMM. METHODS A total of ten specimens from eight unique cases of OMM were identi...
#1Yu Min(CQMU: Chongqing Medical University)H-Index: 1
#2Ke Xiang(CQMU: Chongqing Medical University)H-Index: 1
Last. Guobing Yin(CQMU: Chongqing Medical University)H-Index: 1
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BACKGROUND Adolescent differentiated thyroid carcinoma (DTC) is a rare type of thyroid cancer that represents a special entity of all endocrine-related cancer. This study aims to establish the first nomogram for predicting the regional (central and lateral) lymph node metastasis (LNM) in the adolescent population for better surgical management. METHOD We retrospectively reviewed the clinicopathology characteristics of adolescent patients with DTC in the Surveillance, Epidemiology, and End Result...
Abstract null null Objectives null Adenoid cystic carcinoma (ACC) is the malignancy most likely to spread perineurally. Delayed diagnosis often leads to undetected perineural spread (PNS). Better understanding of diagnostic processes, clinical and imaging features in ACC may allow earlier diagnoses. null null null Materials and methods null A retrospective records search of the University of Washington Radiology archive identified patients with palatal ACC diagnosis and pre-treatment MDCT and/or...
Epithelioid rhabdomyosarcoma is a new and rare morphological variant of rhabdomyosarcoma, with only a few reports in the literature. We aimed to describe an atypical case of this variant involving the oral cavity. A 33-year-old male patient presented with an asymptomatic, gingival mass adjacent to the left maxillary canine with progressive growth over approximately 3 months. Microscopic and immunohistochemical assessment of the biopsy specimen were consistent with epithelioid rhabdomyosarcoma. A...