Clinical Implication of Dermatopathic Lymphadenopathy Among Japanese A Report of 19 Cases

Published on Apr 1, 2004in International Journal of Surgical Pathology0.872
· DOI :10.1177/106689690401200205
Masaru Kojima35
Estimated H-index: 35
 (Dokkyo University), S. Nakamura + 9 AuthorsNobuhide Masawa22
Estimated H-index: 22
 (Dokkyo University)
Sources
Abstract
To clarify the clinicopathologic and immunohistochemical features of dermatopathic lymphadenopathy not associated with mycosis fungoides among Japanese, 19 patients were studied. Seventy-four percent of the patients were more than 50 years old (median; 63 years, mean 61 years). Systemic symptoms such as fever were recorded in 68% and multicentric lymphadenopathy was noted in 83% of patients. An association of autoimmune disease or positivity of autoantibodies was recorded in 6 patients. Five patients showed cutaneous hypersensitivity reactions to a drug. Histologically, in addition to the dermatopathic lymphadenopathy, numerous immunoblasts were observed in 2 cases and sheet-like proliferation of mature plasma cells in 3 cases. Various atypical or malignant lymphoproliferative disorders exhibiting immunologic abnormalities such as angioimmunoblastic T-cell lymphoma or autoimmune disease-associated lymphadenopathy frequently occur in middle-aged and elderly patients. At least some of the patients with derm...
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Newest
#1Harry L. IoachimH-Index: 1
#2L. Jeffrey MedeirosH-Index: 84
Last. L. Jeffrey MedeirosH-Index: 1
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Ioachim's lymph node pathology , Ioachim's lymph node pathology , کتابخانه دیجیتال جندی شاپور اهواز
102 Citations
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#1K. Y. Lam (HKU: University of Hong Kong)H-Index: 1
There has been a renewed interest in Langerhans cell histiocytosis in recent years due both to advances in basic research and to improvements in diagnostic and treatment approaches. In this article, we review the various aspects of the disease and the potential implications of these recent scientific researches for our understanding and management of the disorder.
32 CitationsSource
Jul 1, 1991·Blood17.54
#1K J Trainor (Flinders Medical Centre)H-Index: 4
#2M J Brisco (Flinders Medical Centre)H-Index: 21
Last. Alexander A. Morley (Flinders Medical Centre)H-Index: 40
view all 6 authors...
Gene rearrangement and monoclonality have been detected in normal cells and in lymphoproliferative disease by using the polymerase chain reaction and primers for the V and J regions of the Ig heavy chain gene or T-cell receptor gamma-chain gene. Using the Ig primers monoclonality was detected in 20 of 20 normal B-lymphocyte clones and in 39 of 52 cases of various types of B-lymphoproliferative disease, but not in 11 cases of T-lymphoproliferative disease. Using the T-cell receptor primers, monoc...
374 CitationsSource
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#1Shigeo NakamuraH-Index: 82
#1Shoji NakamuraH-Index: 18
Last. Taizan SuchiH-Index: 32
view all 2 authors...
Postthymic (peripheral) T-cell malignancy shows marked diversity in histopathologic appearances as well as in clinical and prognostic aspects. Histologic findings and clinical behavior of 110 cases of the three specific types of low-grade, peripheral T-cell lymphomas, i.e., lymphoepithelioid (LeL), angioimmunoblastic (AILD), and T-zone (TzL) lymphomas, were studied. There were 74 men and 36 women (age range, 24 to 90 years; median, 58). Histologic study of LeL, AILD, and TzL showed prominent rea...
71 CitationsSource
Nov 1, 1988·Archives of Pathology & Laboratory Medicine4.09
#1Edwin Gould (UM: University of Miami)H-Index: 15
#1Gould E (JMH: Jackson Memorial Hospital)H-Index: 1
Last. Ibe Mj (UM: University of Miami)H-Index: 1
view all 4 authors...
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: Dermatopathic lymphadenopathy (DPL) is characterized by lymph node enlargement with reactive process and is generally caused by chronic inflammatory skin disease. Interdigitating reticulum cells (IDCs) with broad cytoplasm, innumerable cytoplasmic interdigitation, and bizarre shaped nuclei are the most striking cell type in DPL. According to the shape of the nucleus, arrangement of the tubulovesicular complexes (TVC) and amount of melanin granules, these cells fall into two types: type I has a...
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Feb 1, 1986·Human Pathology2.73
#1M Weiss LawrenceH-Index: 1
#1Lawrence M. WeissH-Index: 86
Last. Gary S. WoodH-Index: 60
view all 4 authors...
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30 CitationsSource
Jul 1, 1985·American Journal of Pathology3.49
#1J. J. van den OordH-Index: 31
#2C. De Wolf-PeetersH-Index: 48
Last. T. AkagiH-Index: 1
view all 6 authors...
Abstract With the use of in situ immunohistochemical techniques on freshly frozen and paraffin-embedded material from 63 reactive lymph nodes, the cellular composition of T-nodules observed in 30 cases with nodular alteration of the paracortical area was analyzed. T-nodules were composed of S-100 beta + interdigitating reticulum cells (IDRCs), variable numbers of OKT6+ dendritic cells (DCs), high endothelial venules, and a very high T helper/T suppressor ratio because of an enrichment of OKT4+, ...
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AIMS: Dermatopathic reaction is a histopathological finding of the lymph node that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T-cell lymphoma. Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy caused by infection with human T-cell leukemia virus type I (HTLV-1), frequently accompanied by cutaneous lesions. However, detailed clinicopathological characteristics of dermatopathic reaction of lymph nodes...
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Jan 2, 2020·Modern Pathology5.99
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Dermatopathic lymphadenopathy is a distinctive form of paracortical lymph node hyperplasia that usually occurs in the setting of chronic dermatologic disorders. The aim of this study is to update our understanding of the clinicopathologic and immunophenotypic features of dermatopathic lymphadenopathy. The study cohort was 50 lymph node samples from 42 patients diagnosed with dermatopathic lymphadenopathy. The patients included 29 women and 13 men with a median age of 49 years (range, 12–79). Twe...
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Adult onset Still’s disease (AOSD) is a chronic inflammatory disorder involving multiple systems. The symptoms mimic those of lymphomas, therefore, the diagnosis of lymphoma needs to be excluded prior to establishing the diagnosis of AOSD. Another similar condition is dermatopathic lymphadenopathy (DL). In DL, the histopathological appearance of lymph node biopsy may also mimic AOSD. The DL is associated with several systemic pathologies, such as malignant lymphomas, and rarely AOSD. We present ...
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