Original paper
SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli
Abstract
Bacteria can survive antibiotic treatment without acquiring heritable antibiotic resistance. We investigated persistence to the fluoroquinolone ciprofloxacin in Escherichia coli. Our data show that a majority of persisters to ciprofloxacin were formed upon exposure to the antibiotic, in a manner dependent on the SOS gene network. These findings reveal an active and inducible mechanism of persister formation mediated by the SOS response,...
Paper Details
Title
SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli
Published Date
Dec 11, 2009
Journal
Volume
5
Issue
12
Pages
e1000760 - e1000760
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Notes
History