Original paper

Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium

Volume: 1, Issue: 2, Pages: 144 - 157
Published: Jul 1, 2011
Abstract
Dissemination of ovarian tumors involves the implantation of cancer spheroids into the mesothelial monolayer on the walls of peritoneal and pleural cavity organs. Biopsies of tumors attached to peritoneal organs show that mesothelial cells are not present under tumor masses. We have developed a live, image-based in vitro model in which interactions between tumor spheroids and mesothelial cells can be monitored in real time to provide spatial and...
Paper Details
Title
Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium
Published Date
Jul 1, 2011
Volume
1
Issue
2
Pages
144 - 157
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