Periorbital cellulitis with breast cancer

Published on Jun 1, 2003in Journal of the Royal Society of Medicine5.238
· DOI :10.1258/JRSM.96.6.292
Roger Stevens2
Estimated H-index: 2
Jennifer Rusby18
Estimated H-index: 18
Michael D Graham1
Estimated H-index: 1
Periorbital cellulitis is a condition frequently referred to general physicians rather than ophthalmologists. It can be caused by malignant disease.
#1Louise A. Mawn (Visual Sciences)H-Index: 17
#1Louise A. Mawn (Visual Sciences)H-Index: 8
Last. Sean P. Donahue (VUMC: Vanderbilt University Medical Center)H-Index: 44
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Preseptal and orbital cellulitis occur more commonly in children than adults. The history and physical examination are crucial in distinguishing between preseptal and orbital cellulitis. The orbital septum delineates the anterior eyelid soft tissues from the orbital soft tissue. Infections anterior to the orbital septum are classified as preseptal cellulitis and those posterior to the orbital septum are termed orbital cellulitis. Recognition of orbital involvement is important not only because o...
4 CitationsSource
#1Kean T. Oh (UI: University of Iowa)H-Index: 1
#2Mark A. AlfordH-Index: 4
Last. Jeffrey A. NeradH-Index: 22
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A 56-year-old man was seen with signs and symptoms consistent with orbital cellulitis. Computed tomographic scan showed a localized bony defect in the sphenoid wing, on which a biopsy was performed through a lateral orbitotomy. Pathologic examination of the surgical specimen revealed mucinous adenocarcinoma, and metastatic workup revealed an extensive lower esophageal malignant neoplasm.
4 Citations
#1Robert A. Goldberg (Jules Stein Eye Institute)H-Index: 62
#2Jack Rootman (UBC: University of British Columbia)H-Index: 52
Abstract The authors reviewed the clinical and histopathologic records of 38 patients with metastatic orbital tumors. Diplopia, ocular motility limitation, and mass effect with displacement, proptosis, or palpable mass were common signs and symptoms. Enophthalmos occurred in 25% of cases. The authors found that the clinical presentations could be broken down into four generalized syndromes of presentation: infiltrative (20 cases, 53%); mass (14 cases, 37%); inflammatory (2 cases, 5%); and functi...
105 CitationsSource
#1Carol L. Shields (Wills Eye Institute)H-Index: 120
#2Jerry A. ShieldsH-Index: 119
Last. Michael PeggsH-Index: 1
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A review of 35 consecutive cases of tumors metastatic to the orbit revealed that the primary tumor site was breast in 18 cases (51%), prostate in 6 cases (17%), lung in 2 cases (6%), gastrointestinal tract in 2 cases (6%), kidney in 1 case (3%), cutaneous melanoma in 1 case (3%), contralateral choroidal melanoma in 1 case (3%), and unknown in 4 cases (11%). The most common presenting signs and symptoms included diplopia with noncomitant strabismus, proptosis, and a palpable mass. In nine cases (...
92 CitationsSource
#1Keith Jackson (UM: University of Michigan)H-Index: 2
#2Shan R. Baker (UM: University of Michigan)H-Index: 46
Periorbital and orbital cellulitis are clearly two distinct disorders with different etiologies. Periorbital cellulitis is well-documented as a more common infectious process limited to the eyelids in the preseptal region. In contrast, orbital cellulitis represents a more severe, but less common, infection of the orbit posterior to the septum with or without subperiosteal abscess, orbital abscess, or cavernous sinus thrombosis. A retrospective review of the clinical and laboratory data of 137 ca...
87 CitationsSource
#1Jerry A. ShieldsH-Index: 119
#2Brock BakewellH-Index: 2
Last. Joseph C. FlanaganH-Index: 21
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• Six hundred forty-five consecutive biopsies of orbital lesions performed at a major ophthalmic hospital during a 20-year period were used to develop a comprehensive classification of orbital tumors and pseudotumors, excluding thyroid orbitopathy. Although this series has certain bias, it probably closely parallels the incidence of orbital lesions that would prompt a biopsy in an ophthalmic practice. It is hoped that this review, combined with a familiarity of the signs and symptoms of various ...
267 CitationsSource
Cited By2
#1Young Min Park (PNU: Pusan National University)H-Index: 12
#2Jong Ho Park (PNU: Pusan National University)H-Index: 1
Last. Jong Soo Lee (PNU: Pusan National University)H-Index: 17
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Breast cancer is the most common primary source of orbital metastasis. Metastasis occurs through hematogenous spread and predominantly involves the choroid. We present a case of a metastatic subconjunctival mass associated with primary breast cancer. To our knowledge, this is the first reported case of its kind. A 41-year-old woman presented with complaints of conjunctival injection and a foreign body sensation in the left eye. She had a history of breast cancer and had been treated 2 years prev...
1 CitationsSource
Metastasis confined to eyelids are rare, representing less than 1% of malignant eyelid lesions. More than 50% of all eyelid metastasis are reported to have the breast as the most common primary origin. Two cases of metastatic eyelid disease associated with primary breast carcinoma are described. These lesions were the first sign of metastatic systemic disease. Case 1: An 80-year old woman with no significant ophthalmological history complaining of a discrete painless lesion in the left upper eye...
6 CitationsSource