Background. The number of long-term colorectal cancer survivors is increasing. Cancer and its treatment can cause physical and psychological complications, but littleisknownabouthowitimpactsqualityoflife(QOL) over the long term—5, 10, and 15 years after diagnosis. Methods. Cancer survivors were randomly selected from three tumor registries in France, diagnosed in 1990 (1 year), 1995 (1 year), and 2000 (1 year). Controls were randomly selected from electoral rolls, stratifying on gender, age group, and residence area. Participants completed two QOL questionnaires, a fatigue questionnaire, an anxiety questionnaire, and a life conditions questionnaire. An analysis of variance was used to compare QOL scores of cancer survivors by period of diagnosis (5, 10, and 15 years) with those of controls, adjusted for sociodemographic data and comorbidities. Results. We included 344 colon cancer and 198 rectal cancer survivors and 1,181 controls. In a global analysis, survivors reported a statistically and clinically significant lower score in social functioning 5 years after diagnosis and higher scores in diarrhea symptoms 5 and 10 years after diagnosis. In subgroup analyses, rectal cancer affected QOL in the physical dimensions at 5 years and in the fatigue dimensions at 5 and 10 years. Conclusion. Survivors of colorectal cancer may experience the effects of cancer and its treatment up to 10 years after diagnosis, particularly for rectal cancer. Clinicians, psychologists, and social workers must pay special attention to rectal cancer survivors to improve overall management. The Oncologist 2011; 16:000–000
Purpose Among long-term (≥5 years) colorectal cancer survivors with permanent ostomy or anastomosis, we compared the incidence of medical and surgical complications and examined the relationship of complications with health-related quality of life.
In 2007, a total number of 149,000 cancer deaths were observed in France, 89,100 in the male population and 60,600 in the female population, and in 2009, the number of new diagnoses of cancer is estimated to be 346,500, 197,500 among men and 149,000 among women. The most frequent cancers are prostate, lung and colorectal cancers in men, and breast, colorectal and lung cancers in women. Cancer mortality is higher in France than in the USA for men and lower for women. The largest differences betwe...
#1Brad Zebrack(SC: University of Southern California)H-Index: 55
#2Jaehee Yi(SC: University of Southern California)H-Index: 16
Last. Patricia A. Ganz(UCLA: University of California, Los Angeles)H-Index: 138
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This study reports on health status and quality of life (QOL) outcomes in long-term cancer survivors, and potential correlates including cancer type, age at diagnosis, health status, and key sociodemographic variables. Method: One hundred and ninety-three cancer survivors 5–10 years post-diagnosis completed a mailed survey assessing physical and mental health status, QOL, post-traumatic growth, and impact of cancer (IOC). Results: Respondents were comparable to population norms on physical and m...
Last. Dee W. West(Cancer Prevention Institute of California)H-Index: 84
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Background: Most studies that have identified variables associated with the health-related quality of life (HRQL) of patients with colorectal cancer have been cross-sectional or included patients with other diagnoses. The objectives of this study were to identify predictors of HRQL in patients with colorectal cancer and interpret the clinical importance of the results. Methods: We conducted a population-based longitudinal study of patients identified through three regions of the California Cance...
BACKGROUND: The objective of this study was to provide updated estimates of national trends in cancer incidence and mortality for France for 1980-2005. METHODS: Twenty-five cancer sites were analysed. Incidence data over the 1975-2003 period were collected from 17 registries working at the department level, covering 16% of the French population. Mortality data for 1975-2004 were provided by the Inserm. National incidence estimates were based on the use of mortality as a correlate of incidence, m...
The number of long-term cancer survivors (≥5 years after diagnosis) in the U.S. continues to rise, with more than 10 million Americans now living with a history of cancer. Along with such growth has come increasing attention to the continued health problems and needs of this population. Many cancer survivors return to normal functioning after the completion of treatment and are able to live relatively symptom-free lives. However, cancer and its treatment can also result in a wide range of physic...
Aims and objectives This study investigates how long-term colon cancer survivors evaluate their health, functional status and quality of life, and whether there are differences based on age, gender or ethnicity. Methods Thirty long-term survivors of at least stage I colon cancer were interviewed in person between December 2004 and May 2005. The interview protocol included the Medical Outcomes Study 36-Item Short Form, Quality of Life ‐ Cancer Survivor, and study-specific questions that asked abo...
Last. Bruno Salerni(University of Brescia)H-Index: 20
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Aims and background. Current follow-up care programs focus mainly on detection of tumor recurrence or metachronous cancer. Other aspects that affect the quality of life (QoL) of long-term survivors, such as sexual dysfunction, psychological distress or depressive symptoms, have been poorly investigated. We studied these issues, and also investigated the surgeons’ awareness of their patients’ needs in order to determine how to improve follow-up care programs. Methods. QoL of 62 colorectal cancer ...
BACKGROUND. The number of long-term survivors after a cancer diagnosis is increasing, yet relatively few studies have addressed survivors' reported symptoms beyond the initial year after diagnosis. METHODS. The symptom reports of 474 survivors of colon and rectal cancer from 5 US metropolitan areas were collected during 2002-2003 as part a larger study of the quality of care for patients with cancer diagnosed in 1998. The relation between the prevalence of reported symptoms and prior treatments ...
#1Joan R. Bloom(University of California, Berkeley)H-Index: 39
#2Dana M. Petersen(University of California, Berkeley)H-Index: 3
Last. Soo Hyang Kang(University of California, Berkeley)H-Index: 9
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Survival from cancer has improved over the past decade resulting in more long-term survivors. The literature on multi-dimensional quality of life (QOL) among long-term (5+ years) adult survivors is reviewed for each of seven cancer sites (i.e. breast, ovarian, cervical, prostate, colorectal, head and neck, and Hodgkin's disease survivors). Overall, long-term survivors experience good to excellent QOL. Physical domain QOL was the most frequently measured while spiritual domain QOL was the least f...
The aim of this study is to assess the societal burden of colorectal cancer (CRC) survivorship 2–10 years post-diagnosis in terms of (1) societal costs, and (2) quality of life/utilities, and to analyze associated patient characteristics. This is a cross-sectional, bottom-up prevalence-based burden of disease study, conducted from a societal perspective in the Netherlands. In total, 155 CRC survivors were included. Utilities were measured by the EQ-5D-5L, using the Dutch tariffs. A cost question...
Last. Ana Paula Cupertino(URMC: University of Rochester Medical Center)H-Index: 4
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Abstract null null Background null Adult cancer survivors (ACS) are at increased risk for developing various comorbid conditions and having poor health-related quality of life (HRQOL) when compared to adults with no history of cancer. The effect of social and emotional support on HRQOL among ACS is not fully elucidated. The purpose of this study was to understand the role of social and emotional support on HRQOL in ACS and to examine if the association between social and emotional support and HR...
Last. Yoko Kusuba(International University of Health and Welfare)H-Index: 3
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Abstract Background and purpose: Quality of life has multiple aspects, but little is known about the effects of exercise on each domain of it. This systematic review aimed to determine the effects of aerobic, resistance, and mixed exercise on multiple aspects of quality of life in patients with cancer through a meta-analysis. Methods Randomized controlled trials with quality of life were collected, and 20 studies were analyzed. Subgroup analyses were performed according to exercise types. Result...
Uvod: Pocet dlhodobo preživajucich pacientov s rakovinou hrubeho creva a konecnika (CRC), sa zvysuje. Kvalita ich života je len zriedka predmetom skumania. Cieľ: Cieľom studie bolo vyhodnotiť kvalitu života suvisiacu so zdravim (HRQOL) u pacientov dlhodobo preživajucich s CRC a urciť demograficke a klinicke korelacie, ktore významne ovplyvňuju HRQOL pacientov. Metody: Bolo oslovených 162 dlhodobo preživajucich pacientov s CRC v SR, prostrednictvom svojpomocných skupin. Podmienkou pre zaradenie d...
Last. Emily Banks(ANU: Australian National University)H-Index: 61
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Improved survival means that cancer is increasingly becoming a chronic disease. Understanding and improving functional outcomes are critical to optimising survivorship. We quantified physical and mental health-related outcomes in people with versus without cancer, according to cancer type. Questionnaire data from an Australian population-based cohort study (45 and Up Study (n = 267,153)) were linked to cancer registration data to ascertain cancer diagnoses up to enrolment. Modified Poisson regre...
Resume Introduction Peu d’etudes ont explore la situation professionnelle a long terme apres un cancer. Notre objectif etait d’etudier le statut d’emploi des patients en longue remission d’un cancer a cinq, dix ou quinze ans apres diagnostic et de le comparer a celui des sujets sans antecedent de cancer. Methodes A partir des donnees d’une etude transversale, realisee aupres de patients en longue remission d’un cancer du sein, du col uterin ou du cancer colorectal tires au sort a partir de trois...
OBJECTIVE To compare the presence of comorbidities and self-perceived health and social support between long-term cancer survivors and people without a history of cancer from a clinical trial examining the effects of a multiple risk behavior intervention. RESULTS Of the 4259 people studied, 190 (4.46%) were cancer survivors. They had a mean ± SD age of 62.8 ± 7 years vs. 58.7 ± 8 years (P < 0.01) for non-cancer people and were more likely to be on long-term sick leave (11.9 vs. 3.5%, P < 0.001)....
Cost-effectiveness models require quality of life utilities calculated from generic preference-based questionnaires, such as EQ-5D. We evaluated the performance of available algorithms for QLQ-C30 conversion into EQ-5D-3L based utilities in a metastatic colorectal cancer (mCRC) patient population and subsequently developed a mCRC specific algorithm. Influence of mapping on cost-effectiveness was evaluated. Three available algorithms were compared with observed utilities from the CAIRO3 study. Si...
The secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor which plays important role in bacterial infection, inflammation, wound healing and epithelial proliferation. Dysregulation of SLPI has been reported in a variety of human cancers including glioblastoma, lung, breast, ovarian and colorectal carcinomas and is associated with tumor aggressiveness and metastatic potential. However, the pathogenic role of SLPI in colorectal cancer is still unclear. Here we showed that SL...
#1Yuehan Zhang(ANU: Australian National University)H-Index: 1
#2Grace Joshy(ANU: Australian National University)H-Index: 19
Last. Emily Banks(ANU: Australian National University)H-Index: 61
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PURPOSE To quantify physical disability and psychological distress in people with and without colorectal cancer (CRC). METHODS Questionnaire data (2006-2009) from 267,153 Australian general population members aged ≥ 45 years participating in the 45 and Up Study (n = 213,231 following exclusions) were linked to cancer registry and hospital admission data, to ascertain CRC status. Modified Poisson regression estimated adjusted prevalence ratios (PRs) for physical disability and psychological distr...
