A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
Volume: 66, Issue: 2, Pages: 234 - 246
Published: Jan 1, 2006
This study examines the current knowledge of physiological and clinical effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their combination in pharmaceutical preparations. Cannabinoid and vanilloid receptor effects as well as non-receptor mechanisms are explored, such as the capability of THC and CBD to act as anti-inflammatory substances independent of cyclo-oxygenase (COX) inhibition. CBD is demonstrated...