Medical Hypotheses
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#1Phileno Pinge-Filho (UEL: Universidade Estadual de Londrina)H-Index: 20
Abstract null null Blood pathogenic trypanosomatids as Trypanosoma cruzi, the causative agent of Chagas Disease, have specialized systems to export virulence factors into host cells. Extracellular vesicles shed by T. cruzi promote infection susceptibility of host cells. Sterile inflammation is part of the innate immune response to molecules released upon tissue injury and is collectively indicated as damage-associated molecular patterns. The complex regulatory pathways that modulate the generati...
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#2Ligen Yu (NTU: Nanyang Technological University)
Last. Daniel J. Klionsky (UM: University of Michigan)H-Index: 139
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The human immunity has a pivotal role in nutrition acquisition from the pathogens and damaged body tissue during the SARS-CoV-2 virus infection, which may lead to transient overnutrition in the patients, lead to lipotoxicity and further damage in non-adipose tissues, and cause hyperinflammation and cytokine storm in severe cases of COVID-19. In view of this, high-quality clinical trials on restrictive eating should be designed to investigate the possible benefits of food intake restriction on pa...
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#1Nicholas S. Patniyot (University of Texas Health Science Center at Houston)
Abstract null null Alterations within consciousness in schizophrenia can be evidenced by impediments in self-awareness and loss of agency. Ned Block’s definition of access consciousness is applied in order to further delineate cognitive deficits involving reflective thought and autonoetic thinking in persons with schizophrenia. Current theories on the nature and functioning of consciousness are discussed, which include Global Workspace Theory and metarepresentational characterizations. These des...
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#2Alireza Tavilani (IAU: Islamic Azad University)
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#1Rahul Mallick (University of Eastern Finland)H-Index: 3
#2Asim K. Duttaroy (University of Oslo)H-Index: 38
Cancer cells survive and grow despite various advanced anti-cancer therapy. To overcome this antineoplastic resistance, adjuvant therapy is often required to prevent cancer cells' immunoescape capacity. Established tumors build a stressful and hostile microenvironment in order to escape protective innate and adaptive immune responses. Specific conditions and factors within tumors, including hypoxia, nutrient starvation, acidic pH, and increased levels of free radicals, provoke a state of "endopl...
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#1Ki Kwang Oh (Kangwon National University)H-Index: 3
#2Md. Adnan (Kangwon National University)H-Index: 7
Last. Dong Ha Cho (Kangwon National University)H-Index: 17
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Currently, a plethora of information has been accumulated concerning COVID-19, including the transmission pathway of SARs-CoV-2. Thus, we retrieved targets associated with the development of COVID-19 via PubChem. A total of 517 targets were identified, and signaling pathways responded after infection of SARs-CoV-2 in humans constructed a bubble chart using RPackage. The bubble chart result suggested that the key signaling pathway against COVID-19 was the estrogen signaling pathway associated wit...
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#1M. Jardou (French Institute of Health and Medical Research)
#2R. Lawson (French Institute of Health and Medical Research)
The world is currently facing the COVID-19 pandemic that is taking a heavy toll on several countries. While many infected patients have a good prognosis, in some cases the progression can be serious and even lead to death. The commonly seen complications are a cytokine storm and multi-organ failure that require intensive care. The mortality of critically ill patients depends on age, sex, immune state or co-morbidities. There is an urgent need to discover a biomarker to identify early on patients...
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#1Yashar Taghizadegan (IAU: Islamic Azad University)
#2Nader Jafarnia Dabanloo (IAU: Islamic Azad University)H-Index: 9
Last. Ali Sheikhani (IAU: Islamic Azad University)H-Index: 8
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Abstract null null Obstructive Sleep Apnea (OSA) is a common disorder characterized by periodic cessation of breathing during sleep. OSA affects daily life and poses a severe threat to human health. The standard clinical method for identifying and predicting OSA events is the use of Polysomnography signals. null In this paper, a novel scheme based on an ensemble of recurrence plots (RPs) and pre-trained convolutional neural networks (RPCNNs) is proposed to improve the prediction rate of OSA. Fir...
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The COVID-19 or novel coronavirus SARS-CoV-2 pandemic is challenging worldwide healthcare system and severely affecting global economy. Furious efforts to end the pandemic including prevention of spread of SARS-CoV-2, use of antiviral drugs, symptomatic treatments and vaccination are underway. But there are no effective treatments available to save the dying patient in stage 2 (pulmonary) and stage 3 (hyperinflammation) of the infection. The detailed genetic and phenotypical analysis of SARS-CoV...
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#1Kai Li (WHU: Wuhan University)
#2Xiaobo He (WHU: Wuhan University)H-Index: 1
Last. Yongbin Zheng (WHU: Wuhan University)H-Index: 5
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Abstract null null Radical resection for rectal cancer with total mesorectal excision has been widely recognized in mid-low rectal cancer. Although such surgery reduced the tumor recurrence rate and improved the survival rate of patients, the rate of urinary and sexual dysfunction was high after rectal cancer surgery, which might be attributed to pelvic autonomic nerve injury. The present study found that the pelvic autonomic nerves never exist alone. These are always surrounded by tiny capillar...
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