Crystal growth of progesterone metastable and stable polymorphs by polymer induced herteronucleation (PIHn) method

The selective crystallization of progesterone polymorphs prepared by Polymer-Induced Heteronucleation (PIHn) method was investigated. Polyvinyl alcohol (PVA), hydroxypropyl methylcellulose (HPMC), dextran, gelatin, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as heteronucleants. Crystallizations were conducted from 0.5, 10 and 40 mg mL−1 solutions in chloroform at room temperature by solvent evaporation. The samples...