Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues.
Abstract
Leukotriene B4 (LTB4) is a potent chemoattractant for myeloid leukocytes, which express BLT1, the high-affinity receptor for LTB4. We report here that BLT1 is induced substantially in CD8+ effector T cells and at lower amounts in CD8+ central memory T cells. LTB4 elicited BLT1-dependent chemotaxis in effector cells, but not in naive or central memory cells. Intravital microscopy showed that BLT1 signaling induced rapid integrin-mediated arrest...
Paper Details
Title
Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues.
Published Date
Aug 31, 2003
Journal
Volume
4
Issue
10
Pages
965 - 973
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Notes
History