Hydrolyzable tannins from the cores of Cornus officinalis with inhibitory activity in vitro on the formation of advanced glycation end products (AGEs)

In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines [1–3], five phenolic compounds, 1,2,3-tri-O-galloyl-β-d-glucose (1), 1,2,6-tri-O-galloyl-β-d-glucose (2), 1,2,3,6-tetra-O-galloyl-β-d-glucose (3), gallic acid 4-O-β-d-(6-O-galloyl)-glucoside (4), and gallic acid 4-O-β-d-glucoside (5), as well as five other constituents, β-sitosterol, daucosterol, betulinic acid,...