Thinking outside the cell: how cadherins drive adhesion
Abstract
Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain multiple repeats of β-sandwich extracellular cadherin (EC) domains that adopt a similar fold to immunoglobulin domains. The best characterized cadherins are the vertebrate 'classical' cadherins, which mediate adhesion via trans homodimerization between their membrane-distal EC1 domains that extend from apposed cells, and assemble intercellular adherens junctions...
Paper Details
Title
Thinking outside the cell: how cadherins drive adhesion
Published Date
Jun 1, 2012
Journal
Volume
22
Issue
6
Pages
299 - 310
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History