Analysis of the composition of immunoconjugates using size‐exclusion chromatography coupled to mass spectrometry
Volume: 19, Issue: 13, Pages: 1806 - 1814
Published: Jun 8, 2005
Abstract
Recombinant monoclonal antibody drug products play an increasingly important role in the treatment of various diseases. Antibodies are large, multi-chain proteins and antibody preparations often contain several molecular variants, which renders them heterogeneous. The heterogeneity is further increased in immunoconjugates prepared by covalently linking several drug molecules per antibody molecule. As part of the product characterization, the...
Paper Details
Title
Analysis of the composition of immunoconjugates using size‐exclusion chromatography coupled to mass spectrometry
Published Date
Jun 8, 2005
Volume
19
Issue
13
Pages
1806 - 1814
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