Acetylation

Internal medicine

Receptor

Hematopoietic cell

Biology

Activator (genetics)

Gene

Haematopoiesis

HDAC3

Proinflammatory cytokine

STAT protein

Immunology

STAT3

Inflammation

Histone deacetylase

Stem cell

Signal transduction

Histone

Cell biology

Transplantation

Cancer research

Biochemistry

Medicine

HDAC1

Blood

HDAC inhibition reduced proinflammatory cytokines and increased regulatory T-cell number and function after allo-HCT. HDAC inhibition enhanced signal transducer and activator of transcription 3 acetylation and induced indoleamine-2,3-dioxygenase after allo-HCT.

Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans