Review paper
Activity and resistance of trastuzumab according to different clinical settings
Abstract
Trastuzumab, a humanized monoclonal antibody directed against HER2, has shown efficacy in breast cancers; however many patients do not respond to this reagent. Here, we discuss the potential mechanisms of trastuzumab efficacy and resistance in different clinical settings as a step toward optimizing the appropriate application of this antibody. The three major antitumor mechanisms of trastuzumab, i.e., inhibition of proliferation,...
Paper Details
Title
Activity and resistance of trastuzumab according to different clinical settings
Published Date
May 1, 2012
Journal
Volume
38
Issue
3
Pages
212 - 217
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