Overexpression of Jagged‐1 combined with blockade of CD40 pathway prolongs allograft survival
Abstract
Dendritic cells (DCs) have the tolerogenic potential to regulate adaptive immunity and induce allografts acceptance. Here we investigated whether blockade of the CD40 pathway could enhance the immune tolerance induced by DC2.4 cells modified to express Jagged‐1 (JAG1‐DC) in heart transplantation. Results showed that JAG1‐DC treatment combined with anti‐CD40L monoclonal antibody (mAb) administration significantly prolonged cardiac allograft...
Paper Details
Title
Overexpression of Jagged‐1 combined with blockade of CD40 pathway prolongs allograft survival
Published Date
Oct 7, 2014
Journal
Volume
93
Issue
2
Pages
213 - 217
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