Current understanding of klotho
Abstract
Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress. Klotho functions as a cofactor/coreceptor regulating fibroblast growth factor (FGF) 23 signaling. Klotho acts as a glucuronidase and...
Paper Details
Title
Current understanding of klotho
Published Date
Jan 1, 2009
Journal
Volume
8
Issue
1
Pages
43 - 51
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History