Recombinant soluble glypican 3 protein inhibits the growth of hepatocellular carcinoma in vitro

We read with great interest an article by Zittermann et al.1 showing that hepatocellular carcinoma (HCC) cells infected with lentivirus for soluble glypican 3 (sGPC3) expression had a lower proliferation rate. The authors indicated that the growth inhibition might be due to the sGPC3 protein secreted by infected HCC cells. Here, we provide direct evidence showing that the sGPC3 protein does in fact inhibit the growth of HCC cells in vitro. Our...