Original paper
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy
Abstract
Mitochondrial dysfunction and autophagy are centrally implicated in Parkinson's disease (PD). Mutations in ATP13A2, which encodes a lysosomal P-type ATPase of unknown function, cause a rare, autosomal recessive parkinsonian syndrome. Lysosomes are essential for autophagy, and autophagic clearance of dysfunctional mitochondria represents an important element of mitochondrial quality control. In this study, we tested the hypothesis that loss of...
Paper Details
Title
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy
Published Date
Mar 1, 2012
Journal
Volume
45
Issue
3
Pages
962 - 972
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Notes
History