Immunohistochemical alterations of cajal-like type of tubal interstitial cells in women with endometriosis and tubal ectopic pregnancy.

Published on May 23, 2013in Archives of Gynecology and Obstetrics2.283
· DOI :10.1007/S00404-013-2878-9
Xiao-Jun Yang1
Estimated H-index: 1
(WMU: Wenzhou Medical College),
Jian-Ying Xu1
Estimated H-index: 1
(Soochow University (Taiwan))
+ 1 AuthorsJing Zhao1
Estimated H-index: 1
(WMU: Wenzhou Medical College)
Sources
Abstract
Purpose The aim of the study was to observe alterations of pacemaker cells termed cajal-like type of tubal interstitial cells (t-ICC) in oviduct from early-stage EMs and tEP, discuss underlying mechanisms and potential role in tubal factor infertility (TFI).
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Endometriosis has been estimated to affect up to 10–15% of reproductive aged women (1). The association between endometriosis and infertility is well supported throughout the literature, but a definite cause-effect relationship is still controversial. The prevalence of endometriosis increases dramatically to as high as 25%–50% in women with infertility and 30–50% of women with endometriosis have infertility (2). The fecundity rate in normal reproductive age couples without infertility is estimat...
255 CitationsSource
#1Xiao-Jun Yang (Soochow University (Suzhou))H-Index: 1
#2Wei Wei (WMU: Wenzhou Medical College)H-Index: 1
Last. Fei-Yun Zheng (WMU: Wenzhou Medical College)H-Index: 5
view all 4 authors...
Objective To study the adverse biomechanical effects of methotrexate (MTX) on spontaneous tubal motility and on a widely distributed Cajal-like type of tubal interstitial cells (t-ICC) in rabbits. In our previous study, MTX was confirmed to cause acute endosalpingitis, and ultrastructural and steroid receptor damage in rat's endosalpinx in a dose-dependent manner. Design Differences in spontaneous tubal contractions and cellular distribution of t-ICC in isthmus were evaluated in response to MTX....
7 CitationsSource
#1Rose E. Dixon (UNR: University of Nevada, Reno)H-Index: 14
#2Fiona C. Britton (UNR: University of Nevada, Reno)H-Index: 20
Last. Sean M. Ward (UNR: University of Nevada, Reno)H-Index: 85
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Spontaneous contractions of the myosalpinx are critical for oocyte transport along the oviduct. Slow waves, the electrical events that underlie myosalpinx contractions, are generated by a specialized network of pacemaker cells called oviduct interstitial cells of Cajal (ICC-OVI). The ionic basis of oviduct pacemaker activity is unknown. Intracellular recordings and Ca2+ imaging were performed to examine the role of extracellular and intracellular Ca2+ sources in slow wave generation. RT-PCR was ...
13 CitationsSource
#1Pedro J. Gomez-Pinilla (Mayo Clinic)H-Index: 25
#2Simon J. Gibbons (Mayo Clinic)H-Index: 45
Last. Gianrico Farrugia (Mayo Clinic)H-Index: 83
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Background Aging produces inevitable changes in the function of most organs including the gastrointestinal tract. Together with enteric nerves and smooth muscle cells, interstitial cells of Cajal (ICC) play a key role in the control of gastrointestinal motility, yet little is known about the effect of aging on ICC. The aim of this study was to determine the effect of aging on ICC number and volume in the human stomach and colon. Methods Gastric and colonic tissues from patients aged 25–70 and 36...
80 CitationsSource
#1Xinghai Yang (Boston Children's Hospital)H-Index: 1
#2Yifan Zhang (Boston Children's Hospital)H-Index: 1
Last. Junbo Hu (Boston Children's Hospital)H-Index: 1
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Abstract Objective The study aimed to analyze the expression and significance of interstitial cells of Cajal (ICC) at the obstruction site of congenital pelviureteric junction obstruction (PUJO). Methods Specimens of the strictured segment of the PUJ were obtained from 24 patients who were diagnosed to have PUJO (without aberrant vessels and adhesive band compression of ureteral junction) intraoperatively. In the control group, PUJ specimens were taken from 21 patients who had Wilms' tumor. Pelv...
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#1Jan D. Huizinga (McMaster University)H-Index: 65
#2Natalia Zarate (QMUL: Queen Mary University of London)H-Index: 22
Last. Gianrico Farrugia (Mayo Clinic)H-Index: 83
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In the last 15 years, our understanding of the cellular basis of gastrointestinal function has been altered irreversibly by the discovery that normal gastrointestinal (GI) motility requires interstitial cells of Cajal (ICC). Research in this relatively short time period has modified our original concept that the core unit that controls motility is made up of nerves and smooth muscle, to one that now includes ICC. This concept has now expanded to beyond the GI tract, suggesting that it may be a f...
122 CitationsSource
#1Sanda Maria Cretoiu (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 19
#2Dragos Cretoiu (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 29
Last. Laurentiu M. Popescu (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 50
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Cells of the female reproductive tract are subject to hormonal control via sex steroid genomic receptors expressed at nuclear level. We previously showed that interstitial Cajal-like cells (ICLC) of human myometrium expressed estrogen and progesterone receptors (ER/PR). Our aim, based on these results, was to see if ER and/or PR could be found also in tubal ICLC. Indeed, we present here immunohistochemical evidence that ICLC of human Fallopian tube (isthmic region) have such receptors. Stromal I...
65 CitationsSource
#1Rose E. Dixon (UNR: University of Nevada, Reno)H-Index: 14
#2Sung Jin Hwang (UNR: University of Nevada, Reno)H-Index: 17
Last. Sean M. Ward (UNR: University of Nevada, Reno)H-Index: 85
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Chlamydia trachomatis is a common sexually transmitted bacterial infection that results in health care costs in the United States that exceed $2 billion per year. Chlamydia infections cause damage to the oviducts, resulting in ectopic pregnancy and tubal factor infertility, but the reasons for defective oviduct function are poorly understood. We have investigated the role of oviduct contractions in egg transport and found that underlying electrical pacemaker activity is responsible for oviduct m...
65 CitationsSource
BACKGROUND: Ectopic pregnancy (EP) is a major reproductive health issue, whose underlying causes remain largely unknown. The unusual macrophage presence in the oviduct affected by EP could indicate macrophage contribution to the pathology. METHODS: Macrophages have important functions in reproduction that are reviewed in this work. They are needed for tissue remodelling and immune-regulatory roles, and are present both in the ovary and uterus. Numerous cytokines regulate monocytes recruitment, d...
16 CitationsSource
#1Stefan Kissler (Goethe University Frankfurt)H-Index: 19
#2Stephan Zangos (Goethe University Frankfurt)H-Index: 29
Last. Manfred Kaufmann (Goethe University Frankfurt)H-Index: 70
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Abstract: The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, sperm is transported in the preovulatory phase to maximize fertility, and third, the human embryo is placed in an adequate setting during implantation. Endometriosis is a gynecologic disorder leading to severe pain symptoms such as severe pain during menstruation (dysmenorrhea), chronic pelvic pain, pain during sexual intercourse ...
54 CitationsSource
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Last. Silviu Cristian Voinea (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 6
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Abstract null null Telocytes (TCs) are interstitial cells that distinguish themselves through their particular architecture, consisting of a relatively small cell body that emits remarkably long and narrow prolongations called telopodes (Tps). Previously known as interstitial Cajal-like cells, TCs manage to develop complex networks in almost all organs of the human body. Although staining positively for vimentin antibody, some uncertainty still persists over the mesenchymal origin of these cells...
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#1Christopher J. Hill (University of Liverpool)H-Index: 4
#2Marwa Fakhreldin (HealthPartners)H-Index: 1
Last. Dharani K. Hapangama (HealthPartners)H-Index: 21
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Endometriosis is a common, oestrogen driven chronic condition, where endometrium-like epithelial and stromal cells exist in ectopic sites. At present, no curative treatments are available and the existing evidence for disease progression is conflicting. The pathogenesis is still unknown and evidently complex, as mechanisms of initiation may depend on the anatomical distribution of endometriotic lesions. However, amongst the numerous theories and plethora of mechanisms, contributions of the fallo...
8 CitationsSource
#1Ivan Varga (Comenius University in Bratislava)H-Index: 17
#2Martin Klein (Comenius University in Bratislava)H-Index: 5
Last. Stefan Polak (Comenius University in Bratislava)H-Index: 14
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Abstract Uterine telocytes are interstitial cells characterized by a very long cytoplasmic prolongations, which form a 3D network, functionally integrating a wide variety of different cells. Leiomyomas (uterine fibroids) are benign tumors, which pose a huge threat concerning various health problems in women affected by this condition. The exact cause of leiomyomas development is, however, still largely unknown. Therefore, in an attempt to clarify their etiology, we performed an immunohistochemic...
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Telocytes are a special type of interstitial cells characterized by distinctive cellular extensions with alternating thin segments (podomers) and dilations (podoms). Telocytes establish contact with v
25 CitationsSource
#1Ivan Varga (Comenius University in Bratislava)H-Index: 17
#2L Urban (Comenius University in Bratislava)H-Index: 4
Last. Stefan Polak (Comenius University in Bratislava)H-Index: 14
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Purpose Key discoveries of recent years comprise detection of telocytes. These cells of connective tissue have extremely long cytoplasmic processes through which they form functionally connected spatial networks. Through their processes they mutually contact and functionally connect also cells of the immune system, nerve fibres and smooth muscle cells. They are located in various parts of the female reproductive system where they can perform specifically significant functions, which are summariz...
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#1Sanda Maria Cretoiu (UMFCD: Carol Davila University of Medicine and Pharmacy)H-Index: 19
The seminal work of Popescu and colleagues first demonstrated the existence of a new cell type – the telocytes. We were among the first who reported the presence of such cells in the female genital tract and performed TEM examinations, as well as immunohistochemical staining in the attempt to find a specific marker. Telocytes from rat and from the human uterus and from human fallopian tube were extensively investigated initially by comparison with interstitial cells of Cajal. Progress in telocyt...
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#1Bassem Refaat (UQU: Umm al-Qura University)H-Index: 15
#2Elizabeth Dalton (UNSW: University of New South Wales)H-Index: 1
Last. William J. Ledger (UNSW: University of New South Wales)H-Index: 82
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Background Ectopic pregnancy (EP) is the leading cause of maternal morbidity and mortality during the first trimester and the incidence increases dramatically with in vitro fertilisation and embryo transfer (IVF-ET). The co-existence of an EP with a viable intrauterine pregnancy (IUP) is known as heterotopic pregnancy (HP) affecting about 1% of patients during assisted conception. EP/HP can cause significant morbidity and occasional mortality and represent diagnostic and therapeutic challenges, ...
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#1Xiao-Jun Yang (Soochow University (Suzhou))H-Index: 4
#2Jian Yang (Soochow University (Suzhou))H-Index: 2
Last. Zong-Ji Shen (Soochow University (Suzhou))H-Index: 4
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Women with endometriosis (EMs) have unexplained infertility. The recently identified telocytes (TCs) might participate in the maintenance of structural and functional integrity of oviduct tissue, but so far the involvement of TCs in EMs-affected oviduct tissue and potential impact on fertility capacity remain unknown. By an integrated technique of haematoxylin and eosin staining, in situ immunohistochemistry and double-labelled immunofluorescence staining and electron microscopy approach, TCs we...
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#1Libo Zhu (ZJU: Zhejiang University)H-Index: 2
#1Libo Zhu (ZJU: Zhejiang University)H-Index: 6
Last. Xinmei Zhang (ZJU: Zhejiang University)H-Index: 14
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Oviduct tubal motility is thought to be controlled by hormones and nerves and has been associated with endometriosis. However, it is still not known whether the fallopian tubes in women with endometriosis demonstrate an abnormal distribution of nerve fibers. The objective of this study was to determine the distribution of nerve fibers in the oviduct isthmus in women with and without endometriosis. Histological sections of the oviduct isthmus tissues were obtained from women undergoing hysterecto...
2 CitationsSource