A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters
Abstract
Wild-type human butyrylcholinesterase (BuChE) has proven to be an efficient bioscavenger for protection against nerve agent toxicity. Human acetylcholinesterase (AChE) has a similar potential. A limitation to their usefulness is that both cholinesterases (ChEs) react stoichiometrically with organophosphosphorus (OP) esters. Because OPs can be regarded as pseudo-substrates for which the dephosphylation rate constant is almost zero, several...
Paper Details
Title
A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters
Published Date
Sep 1, 2008
Volume
175
Issue
1-3
Pages
273 - 280
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