Properties of the urn randomization in clinical trials
Abstract
In this article we review the important statistical properties of the urn randomization (design) for assigning patients to treatment groups in a clinical trial. The urn design is the most widely studied member of the family of adaptive biased-coin designs. Such designs are a compromise between designs that yield perfect balance in treatment assignments and complete randomization which eliminates experimental bias. The urn design forces a...
Paper Details
Title
Properties of the urn randomization in clinical trials
Published Date
Dec 1, 1988
Journal
Volume
9
Issue
4
Pages
345 - 364
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