Pregnancy-associated Changes in the Hemostatic System

Pregnancy, from implantation to parturition, presents unique and profound challenges to a women's hemostatic system. During pregnancy, potentially catastrophic bleeding can occur during implantation and endovascular trophoblast invasion of the maternal spiral arteries. The risk of hemorrhage reaches a peak during the third stage of labor when the placenta is shorn from the decidua basalis exposing 120 spiral arteries largely denuded of their...