Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice.

Published on May 1, 2014in Pharmacology, Biochemistry and Behavior3.533
· DOI :10.1016/J.PBB.2014.02.015
In Ho Jung6
Estimated H-index: 6
(Kyung Hee University),
Hyung Eun Lee16
Estimated H-index: 16
(Kyung Hee University)
+ 9 AuthorsJong Hoon Ryu55
Estimated H-index: 55
(Kyung Hee University)
Sources
Abstract
Abstract Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa . This study investigated the effect of spinosin on cholinergic blockade-induced memory impairment in mice. Behavioral tests were conducted using the passive avoidance, Y-maze, and Morris water maze tasks to evaluate the memory-ameliorating effect of spinosin. Spinosin (10 or 20 mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive impairment in these behavioral tasks with a prolonged latency time in the passive avoidance task, an increased percentage of spontaneous alternation in the Y-maze task and a lengthened swimming time in target quadrant in the Morris water maze task. In addition, a single administration of spinosin in normal naive mice also enhanced the latency time in the passive avoidance task. To identify the mechanism of the memory-ameliorating effect of spinosin, receptor antagonism analysis and Western blotting were performed. The ameliorating effect of spinosin on scopolamine-induced memory impairment was significantly antagonized by a sub-effective dose (0.5 mg/kg, i.p.) of 8-hydroxy-2-(di-N-propylamino)tetralin, a 5-HT 1A receptor agonist. In addition, spinosin significantly increased the expression levels of phosphorylated extracellular signal-regulated kinases and cAMP response element-binding proteins in the hippocampus. Taken together, these results indicate that the memory-ameliorating effect of spinosin may be, in part, due to the serotonergic neurotransmitter system, and that spinosin may be useful for the treatment of cognitive dysfunction in diseases such as Alzheimer's disease.
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In the present study, we investigated the effect of ethanolic extract of the seed of Zizyphus jujuba var. spinosa (EEZS) on cholinergic blockade-induced memory impairment in mice. Male ICR mice were treated with EEZS. The behavioral tests were conducted using the passive avoidance, the Y-maze, and the Morris water maze tasks. EEZS (100 or 200 mg/kg, p.o.) signifi cantly ameliorated the scopolamine-induced cognitive impairment in our present behavioral tasks without changes of locomotor activity....
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