Original paper
Interaction of oxicam NSAIDs with DMPC vesicles: differential partitioning of drugs
Abstract
Small unilamellar vesicles (SUVs) formed by the dimyristoylphosphatidylcholine (DMPC), a phospholipid; serve as a membrane mimetic system that can be used to study the effect of absence of net surface charges on drug–membrane interaction. The targets of non-steroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenases, which are membrane active enzymes. Hence, to approach their targets NSAIDs have to pass different bio-membranes. Different...
Paper Details
Title
Interaction of oxicam NSAIDs with DMPC vesicles: differential partitioning of drugs
Published Date
Dec 1, 2005
Volume
138
Issue
1-2
Pages
20 - 28
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Notes
History