The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
Volume: 148, Issue: 3, Pages: 431 - 437
Published: Mar 1, 2010
Abstract
This study investigated the role of TRPA1 in the development and maintenance of mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's Adjuvant (CFA) in mice. The intraplantar (i.pl.) injection of CFA induced a long lasting (28 days) hyperalgesia for both mechanical and thermal (cold) stimuli. The intraperitoneal (i.p., 30–300 mg/kg), intraplantar (i.pl., 100 μg/site) or intrathecal (i.t., 10 μg/site) injection...
Paper Details
Title
The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
Published Date
Mar 1, 2010
Volume
148
Issue
3
Pages
431 - 437
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