Original paper
Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells
Volume: 75, Issue: 2, Pages: 411 - 420
Published: Dec 28, 2014
Abstract
Purpose
Cks1, a conformationally heterogenous 9 kDa protein, is markedly overexpressed in cancer cells and contributes to tumor development. Cks1 is an essential component of the SCF-Skp2 ubiquitin ligase complex that targets the Cdk inhibitors p27Kip1 and p21Cip1. Cks1 is known to interact with the Hsp90-Cdc37 chaperone machinery, although whether this facilitates its conformational maturation and stability is not known. To test whether...
Paper Details
Title
Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells
Published Date
Dec 28, 2014
Volume
75
Issue
2
Pages
411 - 420
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Notes
History