Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress

Supplementation with 10% liquid fructose to female rats for 2 weeks caused hepatic steatosis through increased lipogenesis and reduced peroxisome proliferator activated receptor (PPAR) α activity and fatty acid catabolism, together with increased expression of the spliced form of X-binding protein-1 (Rebollo et al., 2014). In the present study, we show that some of these effects are preserved after sub-chronic (8 weeks) fructose supplementation,...