Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments

Chemical exchange saturation transfer (CEST) is a contrast mechanism that exploits exchange‐based magnetization transfer (MT) between solute and water protons. CEST effects compete with direct water saturation and conventional MT processes, and generally can only be quantified through an asymmetry analysis of the water saturation spectrum ( Z ‐spectrum) with respect to the water frequency, a process that is exquisitely sensitive to magnetic...