ALTERATION OF RETICULOENDOTHELIAL PHAGOCYTIC FUNCTION AND TUMOR NECROSIS FACTOR-?? PRODUCTION AFTER TOTAL HEPATIC ISCHEMIA1

Background This study was conducted to determine whether the duration of total hepatic ischemia influences reticuloendothelial phagocytic activity and tumor necrosis factor (TNF)-α production after reperfusion. Methods Male rats pretreated with either normal saline (NS group) or gadolinium chloride (7 mg/kg) for 2 days to inhibit Kupffer cell function (GC group) were subjected to 30, 60, or 90 min of total hepatic ischemia. Results The animals...