Microbial-based therapy of cancer: Current progress and future prospects

The use of bacteria in the regression of certain forms of cancer has been recognised for more than a century. Much effort, therefore, has been spent over the years in developing wild-type or modified bacterial strains to treat cancer. However, their use at the dose required for therapeutic efficacy has always been associated with toxicity problems and other deleterious effects. Recently, the old idea of using bacteria in the treatment of cancer...