Methionine aminopeptidase 2 inhibition: antiangiogenesis and tumour therapy
Abstract
Methionine, used to initiate protein synthesis in eukaryotes, is largely recovered as a co-translational hydrolysis event catalysed by two related enzymes, methionine aminopeptidase (MetAP)1 and 2. One of these, MetAP2, is covalently modified, and thus catalytically inactivated, by a class of drugs related to the fungal polyene antibiotic, fumagillin. This irreversible inhibition results in cell cycle arrest in endothelial cells (as well as a...
Paper Details
Title
Methionine aminopeptidase 2 inhibition: antiangiogenesis and tumour therapy
Published Date
Jan 1, 2004
Volume
14
Issue
1
Pages
1 - 6
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