Original paper
Inhibition of clot-bound alpha 2-antiplasmin enhances in vivo thrombolysis.
Abstract
Recent experiments in vitro have shown that inhibition of human alpha 2-antiplasmin by a monoclonal antibody (MAb RWR) markedly enhances clot lysis by plasminogen activators. To extend these studies in vivo, we tested whether inhibition of clot or fibrin-bound alpha 2-antiplasmin by MAb RWR could enhance the lysis of a human clot by tissue-type plasminogen activator (t-PA) in a rabbit jugular vein thrombosis model. Compared with a saline placebo...
Paper Details
Title
Inhibition of clot-bound alpha 2-antiplasmin enhances in vivo thrombolysis.
Published Date
Jul 1, 1990
Journal
Volume
82
Issue
1
Pages
164 - 168
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Notes
History