Original paper
Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia
Abstract
Eosinophilic inflammation, which may be a consequence of interleukin-5 action, is a characteristic feature of some forms of asthma. However, in three previous clinical trials involving patients with asthma, blockade of this cytokine did not result in a significant improvement in outcomes. We studied the prednisone-sparing effect of mepolizumab, a monoclonal antibody against interleukin-5, in a rare subgroup of patients who have sputum...
Paper Details
Title
Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia
Published Date
Mar 5, 2009
Volume
360
Issue
10
Pages
985 - 993
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Notes
History