Original paper
Structural Complementation of the Catalytic Domain of Pseudomonas Exotoxin A
Abstract
The catalytic moiety of Pseudomonas exotoxin A (domain III or PE3) inhibits protein synthesis by ADP-ribosylation of eukaryotic elongation factor 2. PE3 is widely used as a cytocidal payload in receptor-targeted protein toxin conjugates. We have designed and characterized catalytically inactive fragments of PE3 that are capable of structural complementation. We dissected PE3 at an extended loop and fused each fragment to one subunit of a...
Paper Details
Title
Structural Complementation of the Catalytic Domain of Pseudomonas Exotoxin A
Published Date
Feb 1, 2014
Journal
Volume
426
Issue
3
Pages
645 - 655
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Notes
History