Original paper
Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure–Activity Relationship Studies on Euphorbia Factor L3 Derivatives
Abstract
Five series of 37 new acylate and epoxide derivatives (3–39) of Euphorbia factor L3, a lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp). Eight derivatives exhibited greater chemoreversal ability than...
Paper Details
Title
Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure–Activity Relationship Studies on Euphorbia Factor L3 Derivatives
Published Date
Apr 22, 2015
Volume
58
Issue
9
Pages
3720 - 3738
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