Antifibrotic effect of adipose stromalcells on chondrocytes from osteoarthritic patients

Purposes

Osteoarthritis (OA) characterised by degeneration of articular cartilage is the most frequent rheumatic disease. Mesenchymal stem cells (MSC) isolated from bone marrow (MSC) or adipose tissues (ASC) secrete a large amount of factors with immunomodulatory, proliferative, antifibrotic or antiapoptotic properties. The possibility that these cells, through their trophic potential, may influence the course of chronic degenerative...