Clinical evidence for an association between familial adenomatous polyposis and type II diabetes

Recent genome wide association (GWA) studies suggested that type II diabetes (T2D) is associated with TCF7L2 (or TCF4) polymorphisms.1 TCF7L2/TCF4 is a transcription factor involved in the Wnt-signaling pathway, which plays an important role in colorectal carcinogenesis.Familial adenomatous polyposis (FAP) is a syndrome caused by germline mutations in the APC gene. APC gene defects lead to nuclear accumulation of β-catenin, and formation of...