Salvage radiotherapy after prostatectomy – What is the best time to treat?

Salvage radiotherapy (SRT) is applied routinely in patients with biochemical relapse after radical prostatectomy (RP). However, only ∼30% of these patients achieve a durable response after 10 years. As a standard, 66 Gy are given, ideally with a PSA below 0.5 ng/ml. We tried to determine more precisely the optimal PSA for starting SRT.In 301 prostate cancer patients without hormonal treatment, we analysed the impact on the biochemical response...