The Role of Capillary Perfusion in the Management of Diabetic Macular Edema

The presence of nonperfusing capillaries in diabetic retinopathy was first described by Ashton using the india ink injection techni­ que. Cogan and associates· subsequently demonstrated acellular capillary zones in trypsin digestion flat retinal preparations. The latter authors interpreted these acellular capillaries as nonperfusing, based on the ab­ sence of red blood cells in the lumen, and suggested that the capillary closure was sec­ ondary...