The Fibroblast Growth Factor signaling pathway

The signaling component of the mammalian Fibroblast Growth Factor ( FGF ) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors ( FGFRs ). Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins. Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic...