: A 28-year old woman with ovarian choriocarcinoma developed a uveitis in her left eye. Subsequently, a mass was observed in the anterior segment of that eye together with a subconjunctival mass that appeared to extend from it. Biopsy of the subconjunctival nodule showed two different cell types consistent with the cytotrophoblastic and syncytiotrophoblastic elements typical and choriocarcinoma. No abnormalities of the posterior segment were found on careful examination. Treatment consisted of systemic chemotherapy with a variety of therapeutic agents, argon laser photocoagulation of tumor seedings in the anterior chamber angle, radiation to the eye, and finally, subconjunctival injections of methotrexate. The eye became blind and painful and was enucleated. Histopathologic examination revealed residual tumor cells in the anterior segment indicating treatment changes, but there were no abnormalities posteriorly. Choriocarcinoma metastatic to the eye has been reported infrequently, and this is the first case in which anterior segment metastases have been observed and the effects of treatment thoroughly documented.
Last. Daniel M. Albert(MEE: Massachusetts Eye and Ear Infirmary)H-Index: 68
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A rare metastatic choroidal tumor from primary mediastinal choriocarcinoma in a male is described. This tumor secreted gonadotrophins and showed the histopathologic characteristics of cytotrophoblast and syncytiotrophoblast cells. Early metastatic disease resulted in rapid death; the development of the choroidal metastatic lesion was diagnosed at autopsy.
Presentation of Case A 27-year-old woman was admitted to the hospital because of a pulmonary mass. She was well until six years previously, when her first pregnancy terminated in a spontaneous abortion in the first trimester. A daughter was born two years later of a full-term normal delivery. Three years before admission a third pregnancy also ended in a spontaneous abortion in the first trimester; dilatation and curettage was not performed. Her physician stated that she had ovarian cysts that i...
In 26 of 227 patients with carcinoma metastatic to the eye or orbit, metastasis to the anterior uveal tract was the predominating feature. There was a definite propensity for the tumor to involve the horizontal meridian of the iris or ciliary body, rather than the upper or lower portions. The site of the primary tumor in the 26 patients was as follows: lung, 14; breast, 9; kidney, 2; and rectum, 1. Ocular symptoms and signs produced by the metastatic tumors at onset or during the course of the d...
Of 227 cases of carcinoma metastatic to the eye or orbit, the predominant involvement was in the eye in 196 cases, the orbit in 28, and in the optic nerve in 3 cases. There was no preponderance of left-sided involvement. The primary sites accounting for the most cases were the breast (40%) and the lung (29%). Of the 217 patients regarding whom follow-up information was obtainable, 192 were known to have died of metastatic tumor. The median survival was 7.4 months from the time of ocular/orbital ...
Abstract This study reports results of therapy in 91 patients with metastatic gestational trophoblastic disease treated by physicians of the Southeastern Regional Trophoblastic Disease Center. The 91 patients were grouped into good (79 per cent) or poor (19 per cent) prognostic categories. “Poor prognosis” patients were identified by the presence of an initial pretreatment human chorionic gonadotropin (HCG) titer greater than 100,000 I.U. per 24 hours, duration of disease greater than 4 months, ...
Abstract Considerable progress has been made in recent years in the understanding and management of a family of gestational and nongestational tumors of chorionic origin. The occurrence of the gest...
A 19-year-old pregnant woman with weight loss and pulmonary infiltrates was found to have metastatic choriocarcinoma. A concomitant marked visual loss was associated with multiple elevated choroidal lesions in both eyes. Treatment with methotrexate resulted in clinical remission and striking improvement of vision and fundus appearance.
#1Young Min Park(PNU: Pusan National University)H-Index: 12
#2Jong Ho Park(PNU: Pusan National University)H-Index: 1
Last. Jong Soo Lee(PNU: Pusan National University)H-Index: 17
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Breast cancer is the most common primary source of orbital metastasis. Metastasis occurs through hematogenous spread and predominantly involves the choroid. We present a case of a metastatic subconjunctival mass associated with primary breast cancer. To our knowledge, this is the first reported case of its kind. A 41-year-old woman presented with complaints of conjunctival injection and a foreign body sensation in the left eye. She had a history of breast cancer and had been treated 2 years prev...
Resume Nous rapportons le cas d’un patient de 53 ans adresse par son ophtalmologue traitant pour une gene et une rougeur oculaire. A l’examen clinique, on retrouve un tableau d’uveite anterieure granulomateuse, avec une hypertonie oculaire a 38 mmHg et une masse irienne blanchâtre, neovascularisee ainsi qu’un envahissement de l’angle irido-corneen. Devant la forte suspicion de metastase irienne, un bilan general est realise et met en evidence un carcinome broncho-pulmonaire moyennement differenc...
PURPOSE: To describe a case of choroidal metastasis of choriocarcinoma, which presented as a rapidly progressive hemorrhagic retinal detachment with concurrent optic nerve involvement suggestive of inflammation or metastasis. METHOD: This is a case report of a 43-year-old patient with a known history of choriocarcinoma metastases to both lungs who presented with 1 week of right eye pain and decreased vision. Dilated fundus examination was significant for a large, bullous, hemorrhagic retinal det...
Abstract Background. Gestational choriocarcinoma is a malignant tumor that frequently metastasizes to the highly vascularized organs such as the lung, brain, and liver via hematogenous spread. However, this tumor rarely metastasizes to the eye and only a few cases of metastasis to the choroid have been reported. Case. A 17-year-old woman presented with visual field defects, decreased vision, and increasing pain in her left eye. She had undergone evacuation of a complete hydatidiform mole 32 mont...
Last. Barrett G. Haik(UTHSC: University of Tennessee Health Science Center)H-Index: 38
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Chemotherapy has been used to treat a multitude of eye cancers. We attempted to review the role of chemotherapy in the treatment of ocular, adnexal, and orbital malignancies by conducting an extensive search of the medical literature. Unfortunately, the published reports typically contain few patients with limited follow-up, precluding definitive recommendations. For most eye cancers, multicenter trials will offer the potential to gather the numbers of patients required to determine the clinical...
Chemotherapy has been used to treat a multitude of eye cancers. We attempted to review the role of chemotherapy in the treatment of ocular, adnexal, and orbital malignancies by conducting an extensive search of the medical literature. Unfortunately, the published reports typically contain few patients with limited follow-up, precluding definitive recommendations. For most eye cancers, multi- center trials will offer the potential to gather the numbers of patients required to determine the clinic...
Alle intraokularen Tumoren konnen zu einem Sekundarglaukom fuhren. Bei einer epikritischen Auswertung der Befunde von 2597 Patienten mit intraokularen Tumoren hatten 5% der Tumoraugen zum Zeitpunkt der Diagnose einen erhohten Augeninnendruck [1]. In manchen Situationen ist die intraokulare Neoplasie lebensbedrohend, wahrend andere Tumoren gutartig sind und in ihrer Unterscheidung gegenuber intraokularen Malignomen fur Diagnose und Therapie schwierig sein konnen. Fur viele Patienten mit einem int...
Metastatic lesions to the eye are now widely recognized as the most common neoplasm of this organ. Of historic interest is the fact that the frequency of metastatic disease to the eye, as compared to primary intraocular tumors, was debated as recently as 1976, in a paper by Francois and Hanssens. After reviewing the literature, these authors commented that ‘many authors think that intraocular metastases are much more common and could be the most frequent malignant tumor of the eye, although othe...
Abstract A 52-year-old man presented with blurred vision and a red, painful eye. There was a marked anterior uveitis associated with a solid white lesion on the iris. The differential diagnosis and appropriate diagnostic workup are discussed. The diagnosis of adenocarcinoma of the lung with metastasis to the iris was made.