Enlargement of the Foveal Avascular Zone in Diabetic Retinopathy After Adjunctive Intravitreal Bevacizumab (Avastin) With Pars Plana Vitrectomy

Published on Apr 8, 2009in Journal of Ocular Pharmacology and Therapeutics2.671
路 DOI :10.1089/JOP.2008.0092
Sung Jun Lee11
Estimated H-index: 11
(Yonsei University),
Hyoung Jun Koh28
Estimated H-index: 28
Sources
Abstract
Purpose: The aim of this study was to describe a case of angiographically documented foveal avascular zone (FAZ) enlargement after intravitreal bevacizumab following vitrectomy and intravitreal bevacizumab treatment of a diabetic patient.Methods: This study was done as a case report.Results: A 40-year-old diabetic man was treated with a pars plana vitrectomy and intravitreal bevacizumab for a nonclearing vitreous hemorrhage. Despite successful surgery, the postoperative best-corrected visual acuity was not improved. FAZ area had increased from 1.48 mm2 preoperatively to 1.96 mm2 postoperatively (24.5% increase).Conclusions: Although intravitreal bevacizumab is an effective modality for diabetic retinopathy, it may deteriorate pre-existing retinal ischemia.
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#1Christopher Seungkyu Lee (Yonsei University)H-Index: 20
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PURPOSE: To evaluate the effects of macular ischemia on visual outcomes in patients with diabetic macular edema (DME), after intravitreal bevacizumab injections. METHODS: Data on 59 eyes of 53 consecutive patients treated with intravitreal bevacizumab for DME were retrospectively reviewed. Data from preoperative fluorescein angiography (FA) tests were examined. Patients with an enlarged foveal avascular zone (FAZ), >or=1000 microm, or a broken perifoveal capillary ring at the border of the FAZ, ...
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