Enlargement of the Foveal Avascular Zone in Diabetic Retinopathy After Adjunctive Intravitreal Bevacizumab (Avastin) With Pars Plana Vitrectomy
Published on Apr 8, 2009in Journal of Ocular Pharmacology and Therapeutics2.671
· DOI :10.1089/JOP.2008.0092
Purpose: The aim of this study was to describe a case of angiographically documented foveal avascular zone (FAZ) enlargement after intravitreal bevacizumab following vitrectomy and intravitreal bevacizumab treatment of a diabetic patient.Methods: This study was done as a case report.Results: A 40-year-old diabetic man was treated with a pars plana vitrectomy and intravitreal bevacizumab for a nonclearing vitreous hemorrhage. Despite successful surgery, the postoperative best-corrected visual acuity was not improved. FAZ area had increased from 1.48 mm2 preoperatively to 1.96 mm2 postoperatively (24.5% increase).Conclusions: Although intravitreal bevacizumab is an effective modality for diabetic retinopathy, it may deteriorate pre-existing retinal ischemia.