Towards cytotoxic and selective derivatives of maslinic acid
Abstract
Several novel esters and amides of maslinic acid were prepared. Their evaluation for cytotoxic activity with a panel of human cancer cell lines using a sulforhodamine B (SRB) assay revealed for some of them a noteworthy activity. The results from annexinV-FITC and caspase-assays as well as from DNA laddering experiments provided evidence for an apoptotic cell death. A diacetylated benzylamide (15) induced a G1/G0 arrest in tumor cells. It also...
Paper Details
Title
Towards cytotoxic and selective derivatives of maslinic acid
Published Date
Jan 1, 2014
Volume
22
Issue
1
Pages
594 - 615
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