Identification of a Novel Domain of Fibroblast Growth Factor 2 Controlling Its Angiogenic Properties

Fibroblast growth factor 2 (FGF-2) is a potent factor modulating the activity of many cell types. Its dimerization and binding to high affinity receptors are considered to be necessary steps to induce FGF receptor phosphorylation and signaling activation. A structural analysis was carried out and a region encompassing residues 48–58 of human FGF-2 was identified, as potentially involved in FGF-2 dimerization. A peptide (FREG-48–58) derived from...