ACTH receptor

Peptide hormone

Biology

Biological activity

Endocrinology

Receptor

Biochemistry

Genetics

Bioassay

In vitro

Hormone receptor

Internal medicine

Adrenocorticotropic hormone

Hormone

Medicine

Chemistry

Breast cancer

Cancer

Science

Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma.

Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma